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Sunday, August 4, 2013

Risks for anal cancer

Cervical cancer share the same cause as most anal cancer: namely HPV viruses.   Thus, it is reasonable to be concerns.   Our study done at the West Clinic has just been published in August 2013 at the Obstetrics & Gynecology journal.   

We studied 327 patients with a biopsy-confirmed diagnosis of genital intraepithelial neoplasia (vulvar, vaginal, or cervical) underwent both anal cytology and anoscopy. We identified 64 (46.7%) women with anal intraepithelial neoplasia (which may lead to anal cancer), yielding a prevalence of 19.6%. Immunosuppression, vulvar dysplasia, multiple sexual partners (more than four), smoking history, and history of anal sex were positively associated with anal intraepithelial neoplasia (P<.05). 

We develop a simple predictive model based on the presence or absence of two of three risk factors (VIN, immunosuppression, and history of anal sex).  If you have two out of these 3 risk factors, please discuss with your health care providers about screening test for anal cancer.   

Reference:  Elnaggar AC, Santoso JT.  Risk Factors for anal intraepithelial neoplasia in Women with genital dysplasia.  Obstet  Gynecol .  2013, 122: 218-223
 

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